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M9490117.TXT
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1994-09-03
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Document 0117
DOCN M9490117
TI [The effect of trichosanthin on immunoregulatory T lymphocytes]
DT 9411
AU Bi LQ; Liu JW; Song Y; Third Medical College, Norman Bethune University
of Medical; Science, Changchun.
SO Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1994 Jan;14(1):18-20, 3-4.
Unique Identifier : AIDSLINE MED/94319131
AB The effect of trichosanthin (TCS) on immune system has drawn attentions
of the investigators both at home and abroad. The purpose of this study
is to evaluate the prospects of TCS on autoimmune diseases and
immunodeficiency diseases by detecting the immunoregulatory T
lymphocytes (T8, 2H4, 4B4) count and cellular DNA content under the
influence of TCS with flow cytometer using indirect immunofluorescence
technique and lymphocyte culture in normal subjects and systemic lupus
erythematosus patients. The results showed that the percentage of T8+
cells decreased, 4B4+ cells increased, 2H4+ cells did not markedly
change after adding TCS. The raise of DNA content in S stage was
dose-dependent to TCS, especially in large doses. It is concluded that
TCS could selectively inhibit T8+ cells and could obviously increase the
number of 4B4+ cells. It is suggested that TCS could enhance humoral
immunity through the ratio of immunoregulatory T cells. So TCS might
help immunodeficiency patients such as AIDS to reestablish their immune
system.
DE Adjuvants, Immunologic/PHARMACOLOGY Adult DNA/BIOSYNTHESIS English
Abstract Female Human Leukocyte Count/DRUG EFFECTS Lupus
Erythematosus, Systemic/*IMMUNOLOGY Male T-Lymphocytes,
Regulatory/*IMMUNOLOGY Trichosanthin/*PHARMACOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).